Understanding frameshift variant requires examining multiple perspectives and considerations. Frameshift Mutation - National Human Genome Research Institute. A frameshift mutation in a gene refers to the insertion or deletion of nucleotide bases in numbers that are not multiples of three. This is important because a cell reads a geneβs code in groups of three bases when making a protein.
Frameshift - HGVS Nomenclature. In relation to this, frameshift: a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame. Frameshift Mutation β Definition, Types, Causes, Examples. A frameshift mutation is a genetic alteration caused by the insertion or deletion of nucleotides in a DNA sequence, which shifts the reading frame of codons and results in the production of an altered and typically nonfunctional protein.
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