Understanding cell cycle checkpoints requires examining multiple perspectives and considerations. Cell cycle checkpoints (article) | Khan Academy. This article gives a high-level overview of cell cycle control, outlining the factors that influence a cell’s decision to pause or progress at each checkpoint. Regulation of the cell cycle (article) | Khan Academy.
From another angle, cell cycle checkpoints ensure that the cell cycle moves forward without mistakes. The three major cell cycle checkpoints occur at the G₁/S transition (the G₁ checkpoint), the G₂/M transition (the G₂ checkpoint), and between metaphase and anaphase during mitosis (the M checkpoint). Cell cycle control (video) | Khan Academy. The cell cycle is tightly regulated by checkpoints between the G1 and S phase, and between the G2 and mitosis.
Key proteins, cyclin-dependent kinases and cyclins, control this process. In the article on cell cycle checkpoints, we looked at the why of cell cycle transitions: the factors that a cell considers when deciding whether or not to move forward through the cell cycle. The cell cycle and mitosis review (article) | Khan Academy.
These are the factors that a cell considers when deciding whether or not to move forward through the cell cycle, and include both external cues (like molecular signals) and internal cues (like DNA damage). The cell cycle is composed of interphase (G₁, S, and G₂ phases), followed by the mitotic phase (mitosis and cytokinesis), and G₀ phase. From another angle, understand: regulation of the cell cycle and cancer. Check your understanding of the regulation of the cell cycle and cancer in this set of free, standards-aligned practice questions.
Cancer and the cell cycle | Biology (article) | Khan Academy. In most cases, these changes in activity are due to mutations in the genes that encode cell cycle regulator proteins. Here, we’ll look in more detail at what's wrong with cancer cells. We'll also see how abnormal forms of cell cycle regulators can contribute to cancer.
Moreover, cell communication and cell cycle | AP®︎/College Biology | Khan Academy. Explore the stages of the cell cycle and how cells grow, replicate DNA, and divide. Understand the events of interphase and their role in preparation for division. Pontos de checagem do ciclo celular (artigo) | Khan Academy.
Han, Z., Chatterjee, D., He, D. M., Early, J., Pantazis, P., Wyche, J. H., and Hendrickson, E.
Moreover, evidence for a G2 checkpoint in p53-indepenent apoptosis induction by X-irradiation. Molecular and Cellular Biology, 15 (11), 5849. This perspective suggests that, http://dx.doi.org/10.1128/MCB.15.11.5849 .
📝 Summary
Via this exploration, we've examined the key components of cell cycle checkpoints. These insights do more than enlighten, but also help readers to make better decisions.