Lysosomal Lipid Metabolism And Neurodegeneration Farese And Walther This work led to the discovery of novel lipid synthesis, degradation, and transport pathways whose loss causes neurodegenerative diseases, thus providing a foundation for potential therapeutic interventions. assistant professor of chemical engineering and of genetics, stanford university cited by 9,946 lysosome biology neurodegeneration lipid metabolism organelles.
Monther Abu Remaileh Chemical Engineering To address these questions, our lab uses a multidisciplinary approach to study the biochemical functions of the lysosome in vitro and in vivo. lysosomes are membrane bound compartments that degrade macromolecules and clear damaged organelles to enable cellular adaptation to various metabolic states. His lab focuses on how lysosomal dysfunction contributes to neurodegenerative disease. they began by studying conditions with known genetic causes but unclear biological mechanisms,. Semantic scholar profile for monther abu remaileh, with 48 highly influential citations and 11 scientific research papers. This review explores how altered lipid metabolism, calcium dyshomeostasis, mitochondrial dysfunction, oxidative stress, and impaired autophagic flux contribute to cellular pathobiology in age related neurodegeneration and neuronopathic lysosomal storage disorders.
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Monther Abu Remaileh Knight Initiative Semantic scholar profile for monther abu remaileh, with 48 highly influential citations and 11 scientific research papers. This review explores how altered lipid metabolism, calcium dyshomeostasis, mitochondrial dysfunction, oxidative stress, and impaired autophagic flux contribute to cellular pathobiology in age related neurodegeneration and neuronopathic lysosomal storage disorders. His lab focuses on how lysosomal dysfunction contributes to neurodegenerative disease. Key to lipid catabolism in the lysosome is bis (monoacylglycero)phosphate (bmp), a major lipid constituent of intralysosomal vesicles (ilvs) and a stimulator of lipid degrading. Abu–remaileh will present his work on how dysfunction in lysosomal lipid catabolism drives neurodegenerative diseases at the asbmb 2026 annual meeting. as a teenager, abu–remaileh lived through political upheaval and in an east jerusalem refugee camp for several years. Lysosomal function is critical for organismal homeostasis—mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age associated diseases including cancer, neurodegeneration and metabolic syndrome.
Monther Abu Remaileh Knight Initiative His lab focuses on how lysosomal dysfunction contributes to neurodegenerative disease. Key to lipid catabolism in the lysosome is bis (monoacylglycero)phosphate (bmp), a major lipid constituent of intralysosomal vesicles (ilvs) and a stimulator of lipid degrading. Abu–remaileh will present his work on how dysfunction in lysosomal lipid catabolism drives neurodegenerative diseases at the asbmb 2026 annual meeting. as a teenager, abu–remaileh lived through political upheaval and in an east jerusalem refugee camp for several years. Lysosomal function is critical for organismal homeostasis—mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age associated diseases including cancer, neurodegeneration and metabolic syndrome.
Spotlight Monther Abu Remaileh Stanford University School Of Engineering Abu–remaileh will present his work on how dysfunction in lysosomal lipid catabolism drives neurodegenerative diseases at the asbmb 2026 annual meeting. as a teenager, abu–remaileh lived through political upheaval and in an east jerusalem refugee camp for several years. Lysosomal function is critical for organismal homeostasis—mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age associated diseases including cancer, neurodegeneration and metabolic syndrome.
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