Paul Flicek Agbt Paul flicek of embl's european bioinformatics institute (embl ebi) discusses the cram file format for genomic data compression. videography: jeff dowling, e. As the first step of variant calling for the 1000 genomes project data, we have finished remapping all of the 1000 genomes sequence reads to grch38 with alternative scaffold–aware bwa mem. the resulting alignments are available as cram, a reference based sequence compression format.
Paul Flicek D Sc These alignments represent the first large scale open dataset in this format and should be a useful resource for community efforts to adapt tools to the cram format. Paul flicek the jackson laboratory, university of cambridge verified email at jax.org data science bioinformatics genomics computational biology gene regulation. Flicek completed master of science degrees in both biomedical engineering and computer science and a doctor of science in biomedical engineering focused on computational biology at washington university in st. louis. he graduated from drake university with a bachelor of science in physics. With collaborators, the flicek group pioneered the technique of comparative regulatory genomics to investigate the mechanisms, function, and origin of the mammalian genome using a broad collection of mammalian species.
Paul Flicek D Sc Flicek completed master of science degrees in both biomedical engineering and computer science and a doctor of science in biomedical engineering focused on computational biology at washington university in st. louis. he graduated from drake university with a bachelor of science in physics. With collaborators, the flicek group pioneered the technique of comparative regulatory genomics to investigate the mechanisms, function, and origin of the mammalian genome using a broad collection of mammalian species. Paul graduated from drake university with a bs (magna cum laude) in physics and worked as a health physicist before moving to washington university in st. louis, where he completed msc degrees in both biomedical engineering and computer science en route to a dsc focused on computational biology. As a visiting group leader, paul still leads a research group focusing on comparative regulatory genomics. during his career, he has worked on aspects of genome annotation, comparative genomics, and large scale biological data generation projects, initially with sequencing of the mouse genome. Dna methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts. strand resolved mutagenicity of dna damage and repair. multiple genomic solutions for local adaptation in two closely related species (sheep and goats) facing the same climatic constraints. Mapping the functional human genome and impact of genetic variants is often limited to european descendent population samples.
I Am Paul Cram Creative Paul Cram Paul graduated from drake university with a bs (magna cum laude) in physics and worked as a health physicist before moving to washington university in st. louis, where he completed msc degrees in both biomedical engineering and computer science en route to a dsc focused on computational biology. As a visiting group leader, paul still leads a research group focusing on comparative regulatory genomics. during his career, he has worked on aspects of genome annotation, comparative genomics, and large scale biological data generation projects, initially with sequencing of the mouse genome. Dna methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts. strand resolved mutagenicity of dna damage and repair. multiple genomic solutions for local adaptation in two closely related species (sheep and goats) facing the same climatic constraints. Mapping the functional human genome and impact of genetic variants is often limited to european descendent population samples.
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