The Mechanisms Of T Cell Selection In The Thymus Trends In Immunology

The subject of the mechanisms of t cellselection in the thymustrends in immunology encompasses a wide range of important elements. The Mechanisms of T CellSelection in the Thymus: Trends in Immunology. Here, we discuss novel findings on the transcriptional mechanisms of tissue restricted-antigen expression in the medullary thymic epithelial cells and its effects on T cell selection. A guide to thymic selection of T cells - Nature.

This Review provides an introductory-level overview of our current understanding of the sophisticated thymic selection mechanisms that ensure T cells are useful and safe. This perspective suggests that, t cell selection in the thymus: a spatial and temporal perspective. The selection of a functional and self-tolerant T cell repertoire is coordinated by multiple selection processes that occur during T cell development in the thymus; including positive selection, negative selection, and agonist selection. T-cell selection in the thymus: New routes toward the identification of ....

The understanding of the molecular mechanisms that control positive selection, CD4/CD8 lineage choice, negative selection and T-regulatory selection remains a topic of intense scrutiny. Positive and negative selection of the T cell repertoire: what .... The mutual developmental dependence of the T cell and the stromal cell (i.e. non-T cell) compartments of the thymus, specified by complex receptor-ligand interactions.

Schematic Diagram of T Cell Selection and TRA Expression in the Thymus. Additionally, thymocyte progenitors derived from bone marrow migrate into the cortex, and interact with cortical thymic epithelial cells (cTECs). Low ZAP70 expression drives neonatal T reg cell development. During T cell development in the thymus, some autoreactive CD4 + CD8 − single-positive clones expressing T cell antigen receptors (TCRs) with intermediate avidity for self-antigens escape clonal ...